Brain Rhythms in Object Recognition and Manipulation

Our manual interactions with objects represent the most fundamental activity in our everyday life. Whereas the grasp of an object is driven by the perceptual senses, using an object for its function relies on learnt experience to retrieve. Recent theories explain how the brain takes decisions based on perceptual information, yet the question of how does it retrieve object knowledge to use tools remains unanswered. Discovering the neuronal implementation of the retrieval of object knowledge would help understanding praxic impairments and provide appropriate neurorehabilitation. This thesis reports five investigations on the neuronal oscillatory activity involved in accessing object knowledge. Employing an original paradigm combining EEG recordings with tool use training in virtual reality, I demonstrated that beta oscillations are crucial to the retrieval of object knowledge during object recognition. Multiple evidence points toward an access to object knowledge during the 300 to 400 ms of visual processing. The different topographies of the beta oscillations suggest that tool knowledge is encoded in distinct brain areas but generally located within the left hemisphere. Importantly, learning action information about an object has consequences on its manipulations. Multiplying tool use knowledge about an object increases the beta desynchronization and slows down motor control. Furthermore, the present data report an influence of language on object manipulations and beta oscillations, in a way that learning the name of an object speeds up its use while impedes its grasp. This shred of evidence led to the formulation of three testable hypotheses extending contemporary theories of object manipulation and semantic memory. First, the preparation of object transportation or use could be distinguished by the synchronization/desynchronization patterns of mu and beta rhythms. Second, action competitions originate from both perceptuo-motor and memory systems. Third, accessing to semantic object knowledge during object processing could be indexed by the bursts of desynchronization of high-beta oscillations in the brain.MSCA-ETN SECURE [642667

Impact of Iris Size and Eyelids Coupling on the Estimation of the Gaze Direction of a Robotic Talking Head by Human Viewers

International audiencePrimates - and in particular humans-are very sensitive to the eye direction of congeners. Estimation of gaze of others is one of the basic skills for estimating goals, intentions and desires of social agents, whether they are humans or avatars. When building robots, one should not only supply them with gaze trackers but also check for the readability of their own gaze by human partners. We conducted experiments that demonstrate the strong impact of the iris size and the position of the eyelids of an iCub humanoid robot on gaze reading performance by human observers. We comment on the importance of assessing the robot's ability of displaying its intentions via clearly legible and readable gestures

(Post-)queer citizenship in contemporary republican France

1996 saw the publication of Frédéric Martel’s Le Rose et le noir, a comprehensive study of three decades of gay life in metropolitan France. The predominantly anti-communitarian stance adopted by Martel in the epilogue to the first edition of his work had evolved, by the time of the book’s publication en poche in 2000, into a more nuanced view of the interactions and intersections between queer and republican identities in contemporary France. This development was influenced, in large part, by concrete changes which took place over the second half of the 1990s, centring around the introduction of the PACS in 1999, and leading to an ever-broadening debate. This paper will begin by setting forth the ways in which Martel’s position changed and analysing the attitudinal, social, and legislative backdrop which paved the way for such a change to occur. It will then bring Martel’s work into a dialogue with the writings of Eric Fassin and Maxime Foerster, both of whom have, like Martel, offered crucial analyses of the place of queer citizens within the contemporary French republic. Particular attention will first be paid to the ways in which Fassin, in his writings, has underlined the salience of the ‘droit du sol/droit du sang’ debate, traditionally associated with questions of ethnic belonging, in light of public and political discussions revolving around questions of queer kinship raised by the introduction of the PACS. This will lead into an examination of Foerster’s assertion that gay citizens of the Republic, in the era of the PACS, find themselves in a role previously held by women, in other words, as elements that require integration within a republican model. Foerster argues that this requirement to integrate is indicative of the fact that the traditional republican claim that the citizen is a blank canvas is at best misguided, and, at worst, has been deliberately subverted. This paper will examine the manner in which Martel and Fassin’s observations can be used to further strengthen the points raised by Foerster, concluding with the latter that a true engagement with the issues raised by debates around queer citizenship over the past decade can, in fact, allow the contemporary republican citizen to ‘devenir ceux [qu’il] est’. In other words, the article will conclude that the potential impact of the PACS legislation and the broader discussions it has provoked could be a renegotiation of the relationship between queer citizens and the republic

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.3448Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5 × 10(-8)) distributed across 34 loci. Although wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first genetic association signal specific to wet AMD, near MMP9 (difference P value = 4.1 × 10(-10)). Very rare coding variants (frequency <0.1%) in CFH, CFI and TIMP3 suggest causal roles for these genes, as does a splice variant in SLC16A8. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.We thank all participants of all the studies included for enabling this research by their participation in these studies. Computer resources for this project have been provided by the high-performance computing centers of the University of Michigan and the University of Regensburg. Group-specific acknowledgments can be found in the Supplementary Note. The Center for Inherited Diseases Research (CIDR) Program contract number is HHSN268201200008I. This and the main consortium work were predominantly funded by 1X01HG006934-01 to G.R.A. and R01 EY022310 to J.L.H

Deconstructive Aporias: Quasi-Transcendental and Normative

This paper argues that Derrida’s aporetic conclusions regarding moral and political concepts, from hospitality to democracy, can only be understood and accepted if the notion of différance and similar infrastructures are taken into account. This is because it is the infrastructures that expose and commit moral and political practices to a double and conflictual (thus aporetic) future: the conditional future that projects horizonal limits and conditions upon the relation to others, and the unconditional future without horizons of anticipation. The argument thus turns against two kinds of interpretation: the first accepts normative unconditionality in ethics but misses its support by the infrastructures. The second rejects unconditionality as a normative commitment precisely because the infrastructural support for unconditionality seems to rule out that it is normatively required. In conclusion, the article thus reconsiders the relation between a quasi-transcendental argument and its normative implications, suggesting that Derrida avoids the naturalistic fallacy

Caractériser et prévenir la liquéfaction des sols sous les ouvrages : le projet ISOLATE

International audienceThe ISOLATE project aims at better characterizing the liquefaction of soils under seismic excitations in the lab and on site as well as limiting the damages to structures and lifelines. It is organized through five main topics: 1/ characterization at the scale of the material, 2/ characterization at the scale of the subgrade and assessment of scale effects, 3/ analysis of the effects of liquefaction on structures, 4/ risk reduction and assessment of an innovative mitigation method, 5/ recommendations for practitioners and publicizing the results. The involvement of renowned academic institutions in the fields of geotechnics, seismic risk, experimental, physical and numerical modelling (CEA, CS, ENPC, IFSTTAR) underlies the relevance of the proposed actions; that of major industrial stakeholders (EDF, SB) guarantees that the scientific and technical outcomes of this project will benefit to the economical field.Le projet ISOLATE vise à mieux caractériser le phénomène de liquéfaction des sols sous séisme en laboratoire et in situ et à limiter les dommages sur les ouvrages et les réseaux urbains. Il est organisé autour de cinq thématiques : 1/ caractérisation à l'échelle du matériau, 2/ caractérisation à l'échelle du sol de fondation et évaluation des effets d'échelle, 3/ analyse des effets de la liquéfaction sur les ouvrages, 4/ réduction du risque et évaluation d'une méthode de mitigation innovante, 5/ recommandations pratiques et valorisation des résultats. La participation au projet d'acteurs académiques reconnus dans le domaine de la géotechnique, du risque sismique, de l'expérimentation et de la modélisation physique et numérique (CEA, CS, ENPC, IFSTTAR) sous-tend la pertinence des actions proposées ; celle d'acteurs industriels majeurs (EDF, SB) garantit que les avancées scientifiques et techniques obtenues dans ce projet bénéficieront aux acteurs économiques

Measuring Optimism Bias among Military Personnel

High numbers of young military personnel die due to road traffic collisions (RTCs). Yet, there is a paucity of research related to the contributing factors (i.e., optimism bias and willingness to take risks) associated with RTCs and the examination of road safety education program tailored at reducing young military fatalities. In order to address this gap in the literature, we examined one specific road safety educational intervention tailored for the UK military personnel and investigated their attitudes towards the program, optimism bias and willingness to take risks. Measures evaluating their optimism bias, willingness to take risks and attitudes towards the program were asked after the participants attended the road safety interventions. The results revealed that young military personnel, aged 18-25, had higher optimism bias and willingness to take risks compared to older military personnel, and that this effect diminishes with age. The results provide importance evidence related to military personnel’s attitudes to risk-taking

Coupled hydromechanical modeling to study the integrity and safety of geological storage of CO2

AbstractThe present study provides a set of numerical tools for modeling the geomechanical aspects related to the safety of geological CO2 storage, namely, caprock damage and fault reactivitation due to reservoir pressure rise. Large scale finite element models are used to describe the injection process. The change of the effective stress field is investigated. Different cracking mechanisms are considered to examine the caprock integrity for high injection rates and different initial in situ stress conditions. Last, a special hydromechanical joint element is presented to model the response of the faults / fractures affected by the pressure build-up in the reservoir